Objectives : This study was designed to investigate the association between 5-HTZA receptor gene promoter - 1438A/G polymorphism and schizophrenia in a Korean population.
Method : 5-HTZA receptor gene promoter - 1438A/G polymorphism was typed with Polymerase Chain Reaction in 132 patients with schizophrenia and 138 healthy normal controls.
Result : There was no difference in allelic frequency of - 1438A/G polymorphism between patients with schizophrenia and controls(x2=2.261, df=1, p=:0.133). A difference was found in genotype distribution(x2=6.157, df=2, p=0.046), but this difference was being given by the increased A/A in th controls and A/G in the patients. The genotype frequency, which is the sum of homozygosity and heterozygosity for the - 1438 G allele, was significantly higher in the patients(x2=5.880, df=1, p=0.015). However, there was no difference between the patients with schizophrenia and conrols in the frequency of homozygosity for the - 1438 G allele.
Conclusion : These results suggest that - 1438A/G polymorphism of the 5-HTZA receptor gene promoter is not causally related to the development of schizophrenia in a Korean population.
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